Microbes in our gastrointestinal tract power our immune systems and keep our insulin and blood sugar in balance. Aspartame and other manufactured no-calorie sweeteners are killing them. Action Alert! Artificial sweeteners are among the most widely used food additives worldwide, regularly consumed by lean and obese individuals alike. Products containing artificial sweeteners bring in huge sales figures, and they’re touted as being a safe and healthful alternative to sugar and high-fructose corn syrup.